I agree with you that a .380 is far superior to .22 LR for self defense. However, I would not use Hornady ammo in any striker fired carry pistol. I had some light strikes with their ammo in my R9. When I called them the production manager said that they would obtain their primers from any available source. This would include foreign primers which can be very hard; unlike Federal and Winchester who make their own.
In my experience, striker fired pistols hit the primer with a lot more force than hammer fired pistols. That is why for small pocket carry pistols I think that striker fired ones are much more reliable and that is what I carry.
Hammer fired small pistols like the R9 and the Seecamps are prone to light strikes. You just do not hear about this happening with strker fired small pistols. I have never had an occurance of my R9 not firing on the first pull of the trigger but I have seen primers that are barely dented and went off. The same with Seecamps.
After handloading nearly everything that I have shot in over 35 years, I can say that I have never seen a "Hard Primer". The problem with the round not firing has always been a problem with the seating of the primer. Either the primer pocket is a little undersized or the primer cup is a little over sized and the primer does not get seated clear to the bottom of the pocket and the anvil is not touching the case head.
If you have had a round that does not fire on the first trigger pull but will go on the second, this is the problem. On the first hammer drop the primer is driven down to the proper position so it fires on the second pull. In my experience, strker fired pistols hit hard enough to drive the primer in and fire it on the first pull.
Second strike capability for a DAO pistol is brought up a lot. If your striker fired pistol does not go off on the first pull, you better be jacking another round in the chamber.
JMO