My favorite pistol design is the HK P7.
For decades it was the only pistol I trained with.
When I bought my P7M8 in 1985 I passed up the 3rd Gen Smiths that you hear people rave about today as being such wonderful pistols, I also passed on the Beretta 92, because I made a personal decision for myself that slide mounted safeties that flipped up were not optimal for me. Could I have learned to use them and developed muscle memory and reflexes to bring the guns into action in an emergency - probably, although there was no guarantee I would be able to, and the P7M8 was just much much easier to use.
When I read gun forums and people create these "what gun should I get" threads, I consistency see people underestimating the importance of controls, control placement and whether or not the owner can readily and easily manipulate the controls.
And it is not just a simple matter of flip up / flip down. I tried the safety on the Kahr PM9. I thought it looked like a good idea because I've never had a problem with the flip-down safeties on the 1911 or BHP, but it wasn't until I actually tried to manipulate the safety on the PM9 that I realized it would not work for me.
Just the way it is positioned means I could not do a simple thumb sweep of it to disengage it. I have to bend my thumb and actually place my thumb against it like it is a button - not a lever and then instead of sweeping it down, it is more like dialing a knob.
So if you can imagine dialing a safety down instead of flipping a lever down maybe you get the idea of what the PM9 safety was like.
Anyway I was pretty convinced I wouldn't be able to deploy it in a crunch.