Hey welcome to the forum Wildcat.
Just as few thoughts off the top of my head. First of all, I like the idea of the calibers, and think that they would sell for sure.
However, I can see how they can be more headaches for the factory.
If you add the 9mm in to mix, it is the softest recoiling caliber of the bunch. Right now a lot of folks are really having a lot of feeding and ejecting issues due to the inability to stabilize the pistol correctly. Many blame the gun and send it back to the factory for a check up.
Now add a 40 cal which is snappier than a 45. How many more folks are going to have issues, even those experienced with the R9s? Big difference between a 9mm and 40 in the recoil department. Now, the 357 Sig, not quite as bad, but more so than a 9mm.
Now, a 38 Super, which I LOVE! Those semi-rims can really pose feeding problems. Add a short cyclic recoil system, may spell trouble?
Summary
From a marketing side - yes!
From manufacturing/customer service- no!
That's my view from the saddle