I'm guessing just shoot it, until they get loose? I tried unscrewing them before, w.o. shooting it first, and it didn't go well.
I've decided to have some silver grips made for it -- I think I should be able to get them to fit properly, since I'm using silversmiths who regularly work on pistols. (Have to talk to them first, but I want to show them the grips. Ideally, I'd get hogue to mill them from silver -- might end up doing that, actually. (They, Lopez Bros., regularly work w. Hogue.)