Being a fan of both the Seecamps and the Guardians as BUGs, just let me say that which one you carry should depend on your personal circumstances.
Before my wife requisitioned my LWS32 as her personal weapon, I used to carry it on occasions which I described as "Dress Blue Sundays." (It even sports old-ivory grips.) It is a superb little weapon!
As for the G380, this is a response which I recently posted on the NAA Message Board:
"For me, as the owner of the 64th G380 sold, it is never boring to read success stories about the design. The G380 is an amazing little weapon, as is each model in the the Guardian series. Not only are they practically indestructible but also they represent one of the most reliable designs now available in a pocket pistol. They give new meaning to the 'KISS' principle which I learned to value back in my Army days. In fact, if I had to select one pocket pistol to carry into an environment in which I knew that it would be immersed in 'muck and mud' and might have to be field stripped and cleaned while 'the dreck was hitting the fan,' I would select one of the Guardians. With practice, you can field strip, clean, and reassemble one of those little beauties in less than a minute and in the dark."
And, in closing, let me reaffirm my comments above regarding certain other pocket pistols. But let me also say that if you are expecting to have to crawl through "muck and mud" and may have to field strip and clean a pocket pistol while "the dreck is hitting the fan," you might want to consider having one of the little Guardians in your bag of tricks.
RS